Several manuscripts we collaborated on are published!
The Musselman Lab
They published a nice manuscript characterizing the SANT1 domain of EZH2 using NMR. They find that it recognizes the the histone H4 N-terminal tail and that this binding is antagonized by various activating marks. "The EZH2 SANT1 domain is a histone reader providing sensitivity to the modification state of the H4 tail."
The Weake Lab
They characterized a cool new chiffon histone acetyltransferase (CHAT) complex unique to flies in: "The Drosophila Dbf4 ortholog Chiffon forms a complex with Gcn5 that is necessary for histone acetylation and viability."
Thanks for including us in your awesome science!
Dykhuizen Lab News