Full List:  https://www.ncbi.nlm.nih.gov/pubmed/?term=dykhuizen+e
         

•  De Silva, S. M., Dhiman, A., Sood, S., Mercedes, K. F., Simmons, W. J., Henen, M. A., Vögeli, B., Dykhuizen, E. C., & Musselman, C. A. (2023). PBRM1 bromodomains associate with RNA to facilitate chromatin association. Nucleic acids research. DOI: 10.1093/nar/gkad072​
• Sijie Wang, Marco Hadisurya, W Andy Tao, Emily Dykhuizen, Casey Krusemark. Covalent Protein Inhibitors via Tyrosine Conjugation with Cyclic Imine Mannich Electrophiles. ChemRvix  D O I: 10.26434/chemrxiv-2022-tvgn1
• Saumya M De Silva, Surbhi Sood, Alisha Dhiman, Kilsia F Mercedes, Morkos A Henen, Beat Vögeli, Emily C Dykhuizen, Catherine A Musselman. PBRM1 BD2 and BD4 associate with RNA to facilitate chromatin association. BioRvix doi: https://doi.org/10.1101/2022.02.07.479474 
• Shishodia S, Nuñez R, Strohmier BP, Bursch KL, Goetz CJ, Olp MD, Jensen DR, Fenske TG, Ordonez-Rubiano SC, Blau ME, Roach MK, Peterson FC, Volkman BF, Dykhuizen EC, Smith BC. Selective and Cell-Active PBRM1 Bromodomain Inhibitors Discovered through NMR Fragment Screening.J Med Chem. 2022 Oct 27;65(20):13714-13735.
• Carcamo S, Nguyen CB, Grossi E, Filipescu D, Alpsoy A, Dhiman A, Sun D, Narang S, Imig J, Martin TC, Parsons R, Aifantis I, Tsirigos A, Aguirre-Ghiso JA, Dykhuizen EC, Hasson D, Bernstein E.  Altered BAF occupancy and transcription factor dynamics in PBAF-deficient melanoma. Cell Rep. 2022 Apr 5;39(1):110637. doi: 10.1016/j.celrep.2022.110637.
• Wigton EJ, Mikami Y, McMonigle RJ, Castellanos CA, Wade-Vallance AK, Zhou SK, Kageyama R, Litterman A, Roy S, Kitamura D, Dykhuizen EC, Allen CDC, Hu H, O'Shea JJ, Ansel KM.  MicroRNA-directed pathway discovery elucidates an miR-221/222-mediated regulatory circuit in class switch recombination. J Exp Med. 2021 Nov 1;218(11):e20201422. doi: 10.1084/jem.20201422. 
• Wang S, C Ordonez-Rubiano S, Dhiman A, Jiao G, Strohmier BP, Krusemark CJ, Dykhuizen EC. Polycomb group proteins in cancer: multifaceted functions and strategies for modulation. NAR Cancer. 2021 Oct 4;3(4):zcab039. doi: 10.1093/narcan/zcab039. eCollection 2021 Dec.
• Milosevich N, Wilson CR, Brown TM, Alpsoy A, Wang S, Connelly KE, Sinclair KAD, Ponio FR, Hof R, Dykhuizen EC, Hof F. Polycomb Paralog Chromodomain Inhibitors Active against Both CBX6 and CBX8.  ChemMedChem. 2021 Oct 6;16(19):3027-3034. doi: 10.1002/cmdc.202100262. 
• Wang S, Alpsoy A, Sood S, Ordonez-Rubiano SC, Dhiman A, Sun Y, Jiao G, Krusemark CJ, Dykhuizen EC. A Potent, Selective CBX2 Chromodomain Ligand and Its Cellular Activity During Prostate Cancer Neuroendocrine Differentiation. Chembiochem. 2021 Jul 1;22(13):2335-2344. doi: 10.1002/cbic.202100118.
• Alpsoy A, Sood S, Dykhuizen EC.  At the Crossroad of Gene Regulation and Genome Organization: Potential Roles for ATP-Dependent Chromatin Remodelers in the Regulation of CTCF-Mediated 3D Architecture. Biology (Basel). 2021 Mar 27;10(4):272. doi: 10.3390/biology10040272.
• Alpsoy A, Utturkar SM, Carter BC, Dhiman A, Torregrosa-Allen SE, Currie MP, Elzey BD, Dykhuizen EC.  BRD9 is a critical regulator of androgen receptor signaling and prostate cancer progression. Cancer Res. 2021 Feb 15;81(4):820-833. doi: 10.1158/0008-5472.CAN-20-1417.
• Abdullah A, Akhand SS, Paez JSP, Brown W, Pan L, Libring S, Badamy M, Dykuizen E, Solorio L, Andy Tao W, Wendt MK. Epigenetic targeting of neuropilin-1 prevents bypass signaling in drug-resistant breast cancer. Oncogene. 2020 Oct 30. doi: 10.1038/s41388-020-01530-6.
• Chory EJ, Kirkland JG, Chang CY, D'Andrea VD, Gourisankar S, Dykhuizen EC, Crabtree GR. Chemical Inhibitors of a Selective SWI/SNF Function Synergize with ATR Inhibition in Cancer Cell Killing. ACS Chem Biol. 2020 Jun 19;15(6):1685-1696. doi: 10.1021/acschembio.0c00312. Epub 2020 May 27.
• Kurz L, Miklyaeva A, Skowron MA, Overbeck N, Poschmann G, Becker T, Eul K, Kurz T, Schönberger S, Calaminus G, Stühler K, Dykhuizen E, Albers P, Nettersheim D ARID1A Regulates Transcription and the Epigenetic Landscape via POLE and DMAP1 while ARID1A Deficiency or Pharmacological Inhibition Sensitizes Germ Cell Tumor Cells to ATR Inhibition. Cancers (Basel). 2020 Apr 7;12(4):905. doi: 10.3390/cancers12040905.PMID: 32272809 
• Wang S, Denton KE, Hobbs KF, Weaver T, McFarlane JMB, Connelly KE, Gignac MC, Milosevich N, Hof F, Paci I, Musselman CA, Dykhuizen EC*, Krusemark CJ*. Optimization of Ligands Using Focused DNA-Encoded Libraries To Develop a Selective, Cell-Permeable CBX8 Chromodomain Inhibitor. ACS Chem Biol. 2020 Jan 17;15(1):112-131. doi: 10.1021/acschembio.9b00654. Epub 2019 Dec 12.PMID: 31755685.​

​​                                    *These authors contributed equally to this work

• Cai B, Kim D, Akhand S, Sun Y, Cassell RJ, Alpsoy A, Dykhuizen EC, Van Rijn RM, Wendt MK, Krusemark CJ. Selection of DNA-Encoded Libraries to Protein Targets within and on Living Cells. J Am Chem Soc. 2019 Oct 30;141(43):17057-17061. doi: 10.1021/jacs.9b08085. Epub 2019 Oct 22.PMID: 31613623
• Porter EG, Dhiman A, Chowdhury B, Carter BC, Lin H, Stewart JC, Kazemian M, Wendt MK, Dykhuizen EC. PBRM1 Regulates Stress Response in Epithelial Cells. iScience. 2019 May 31;15:196-210. doi: 10.1016/j.isci.2019.04.027.
• Kulkarni RA, Bak DW, Wei D, Bergholtz SE, Briney CA, Shrimp JH, Alpsoy A, Thorpe AL, Bavari AE, Crooks DR, Levy M, Florens L, Washburn MP, Frizzell N, Dykhuizen EC, Weerapana E, Linehan WM, Meier JL. A chemoproteomic portrait of the oncometabolite fumarate. Nat Chem Biol. 2019 Apr;15(4):391-400
• ​Weaver TM, Liu J, Connelly KE, Coble C, Varzavand K, Dykhuizen EC, Musselman CA. The EZH2 SANT1 domain is a histone reader providing sensitivity to the modification state of the H4 tail. Sci Rep. 2019 Jan 30;9(1):987. doi: 10.1038/s41598-018-37699-w.
• Connelly KE*, Weaver TM*, Alpsoy A, Gu BX, Musselman CA*, Dykhuizen EC​*. Engagement of DNA and H3K27me3 by the CBX8 chromodomain drives chromatin association.  Nucleic Acids Res. 2019 Mar 18;47(5):2289-2305. doi: 10.1093/nar/gky1290.

​​                                    *These authors contributed equally to this work

• Torres-Zelada EF, Stephenson RE, Alpsoy A, Anderson BD, Swanson SK, Florens L, Dykhuizen EC, Washburn MP, Weake VM. The Drosophila Dbf4 ortholog Chiffon forms a complex with Gcn5 that is necessary for histone acetylation and viability.  J Cell Sci. 2019 Jan 16;132(2). pii: jcs214072. doi: 10.1242/jcs.214072.
• Marian CA, Stoszko M, Wang L, Leighty MW, de Crignis E, Maschinot CA, Gatchalian J, Carter BC, Chowdhury B, Hargreaves DC, Duvall JR, Crabtree GR, Mahmoudi T, Dykhuizen EC. (2018) ​Small Molecule Targeting of Specific BAF (mSWI/SNF) Complexes for HIV Latency Reversal. Cell Chem Biol. 2018 Dec 20;25(12):1443-1455.e14. doi: 10.1016/j.chembiol.2018.08.004.
• Soto-Velasquez M, Hayes MP, Alpsoy A, Dykhuizen EC, Watts VJ. A Novel CRISPR/Cas9-Based Cellular Model to Explore Adenylyl Cyclase and cAMP Signaling. (2018) Mol Pharmacol. Sep;94(3):963-972. doi: 10.1124/mol.118.111849.
• Connelly KE, Hedrick V, Paschoal Sobreira TJ, Dykhuizen EC, Aryal UK. (2018) Analysis of Human Nuclear Protein Complexes by Quantitative Mass Spectrometry Profiling. Proteomics. 2018 Jun;18(11):e1700427. doi: 10.1002/pmic.201700427. 
• Alpsoy A, Dykhuizen EC. (2018) Glioma tumor suppressor candidate region gene 1 (GLTSCR1) and its paralog GLTSCR1-like form SWI/SNF chromatin remodeling subcomplexes.  J Biol Chem. 2018 Mar 16;293(11):3892-3903. doi: 10.1074/jbc.RA117.001065. 
• Denton KE, Wang S, Gignac MC, Milosevich N, Hof F, Dykhuizen EC, Krusemark CJ. (2018) Robustness of In Vitro Selection Assays of DNA-Encoded Peptidomimetic Ligands to CBX7 and CBX8.  SLAS Discov. 2018 Jun;23(5):417-428. doi: 10.1177/2472555217750871.
•  Porter EG, Connelly KE, Dykhuizen EC. (2017)  Sequential Salt Extractions for the Analysis of Bulk Chromatin Binding Properties of Chromatin Modifying Complexes. J Vis Exp. Oct 2;(128). doi: 10.3791/55369.
• Porter EG, Dykhuizen EC. (2017) Individual Bromodomains of Polybromo-1 Contribute to Chromatin Association and Tumor Suppression in Clear Cell Renal Carcinoma. J Biol Chem.   Feb 17;292(7):2601-2610.
• Connelly KE, Martin EC, Dykhuizen EC. (2016) CBX Chromodomain Inhibition Enhances Chemotherapy Response in Glioblastoma Multiforme. Yale J Biol Med.  Dec 23;89(4):431-440.
• Connelly KE, Dykhuizen EC. (2016) Compositional and functional diversity of canonical PRC1 complexes in mammals. Biochim Biophys Acta. Dec 20;1860(2):233-245.
• Chowdhury B, Porter EG, Stewart JC, Ferreira CR, Schipma MJ, Dykhuizen EC. (2016) PBRM1 Regulates the Expression of Genes Involved in Metabolism and Cell Adhesion in Renal Clear Cell Carcinoma. PLoS One. Apr 21;11(4):e0153718.
• Stoszko M, De Crignis E, Rokx C, Khalid MM, Lungu C, Palstra RJ, Kan TW, Boucher C, Verbon A, Dykhuizen EC, Mahmoudi T. (2015) Small Molecule Inhibitors of BAF; A Promising Family of Compounds in HIV-1 Latency Reversal. EBioMedicine.  Nov 27;3:108-21. 
• Dykhuizen EC*, Hargreaves DC*, Miller EL, Cui K, Korshunov A, Kool M, Pfister S, Cho YJ, Zhao K, Crabtree GR. (2013) BAF complexes facilitate decatenation of DNA by topoisomerase IIα. Nature. 2013 May 30;497(7451):624-7.
                         *These authors contributed equally to this work
• Dykhuizen EC, Carmody LC, Tolliday N, Crabtree GR, Palmer MA. (2012) Screening for inhibitors of an essential chromatin remodeler in mouse embryonic stem cells by monitoring transcriptional regulation. J Biomol Screen. Oct;17(9):1221-30.
• Dykhuizen EC, Kiessling LL. (2009) Potent ligands for prokaryotic UDP-galactopyranose mutase that exploit an enzyme subsite. Org Lett.  Jan 1;11(1):193-6. 

• Dykhuizen EC, May JF, Tongpenyai A, Kiessling LL. (2008) Inhibitors of UDP-galactopyranose mutase thwart mycobacterial growth. J Am Chem Soc. May 28;130(21):6706-7.
• Carlson CB, Mowery P, Owen RM, Dykhuizen EC, Kiessling LL. (2007) Selective tumor cell targeting using low-affinity, multivalent interactions. ACS Chem Biol. 2007 Feb 20;2(2):119-27
• Stevens SL, Shaw TE, Dykhuizen E, Lessov NS, Hill JK, Wurst W, Stenzel-Poore MP. (2003) Reduced cerebral injury in CRH-R1 deficient mice after focal ischemia: a potential link to microglia and astrocytes that express CRH-R1. J Cereb Blood Flow Metab. 2003 Oct;23(10):1151-9.