Several manuscripts we collaborated on are published!
The Musselman Lab
They published a nice manuscript characterizing the SANT1 domain of EZH2 using NMR. They find that it recognizes the the histone H4 N-terminal tail and that this binding is antagonized by various activating marks. "The EZH2 SANT1 domain is a histone reader providing sensitivity to the modification state of the H4 tail."
The Weake Lab
They characterized a cool new chiffon histone acetyltransferase (CHAT) complex unique to flies in: "The Drosophila Dbf4 ortholog Chiffon forms a complex with Gcn5 that is necessary for histone acetylation and viability."
Thanks for including us in your awesome science!
We are sad to see Jane leave, but happy that she gets to spend more time with family and hobbies. Jane set up the lab and kept everything running for many years. We appreciate everything you've done for us!
After 8 long years, our high throughput screen for BAF inhibitors is published! What a great collaborative effort with the Crabtree Lab, the Broad Institute and the amazing Mahmoudi Lab! These compounds inhibit just a subset of BAF function and serve as HIV latency reversal agents. There's still more to do in order to optimize, characterize and utilize these macrocycles, but we are excited that the first step is published.
Katelyn is hooded and heads out for bigger and better things at the NCI, working in the laboratory of Laufey Amundadottir in the division of epidemiology and genetics. Good luck! We will miss you.
New MCMP graduate student Sandra Ordonez Rubiano joins the lab. She is interested in the chemical biology of chromatin and will be working on the regulation and targeting of PBAF bromodomains.
Congratulations to Katelyn on a successful defense! I may have cried a little.
Students in the lab have had a banner month for fellowships!
Rachel receives the Purdue University Cancer Center undergraduate research fellowship for Summer 2018
Katelyn receives the Bilsland Dissertation Fellowship from the MCMP Department for Fall 2018
Libby receives the Bilsland Dissertation Fellowship from PULSe for the 2018-2019 school year.
Aktan receives the Purdue University Cancer Center SIRG graduate student fellowship for the 2018-2019 school year.
Wow! Congratulations to everyone in lab for your awards of these competitive fellowships!
Katelyn's paper with Dr. Uma Aryal, director of the Purdue Proteomics Facility, describing methods for profiling nuclear complexes is published in Proteomics. Congrats!
Chad is a medicinal chemist with a recent PhD from Dr. Kyle Hadden's lab at UConn. Chad will be working on developing chemical strategies for inhibiting chromatin binding proteins. Welcome!
Dykhuizen Lab News